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MHRA-authorised options include semaglutide (Wegovy) under NICE TA875 and tirzepatide (Mounjaro) under NICE TA1026, both available through specialist NHS weight management services for eligible patients meeting defined BMI and comorbidity criteria

Newer oral GLP-1 options like the Wegovy pill are more affordable currently around $149 per month but clinical trials show they deliver somewhat less weight loss than injectables, averaging around 1516% compared to 20% or more with injections. For patients who need significant weight loss to resolve health conditions, a lower-cost medication that produces fewer results may not be enough

Carnitine: Improves fat metabolism, enhances energy levels, reduces recovery times and boosts muscle-building potential

43 Semaglutide, another next-generation GLP-1 agonist, has a longer half-life, conferring the advantage of weekly subcutaneous injection