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In contrast, a case series by Varadhan et al found in 165 exenatide-treated patients that 30% of the cohort developed or experienced progression of DR

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Extensive transcriptional and chromatin changes underlie astrocyte maturation in vivo and in culture

A GP, pharmacist, or specialist clinician can: Review your current medication list for potential interactions, particularly with diabetes medications, anticoagulants, thyroid treatments, and hormonal contraceptives Assess your nutritional status and advise on appropriate supplementation only where deficiencies are confirmed Monitor for adverse effects such as hypoglycaemia, gastrointestinal disturbance, or unexpected changes in blood pressure or heart rate Refer you to appropriate NHS services , including Tier 3 weight management programmes, if you are seeking structured support for obesity Discuss contraception and family planning , as retatrutide should not be used during pregnancy or breastfeeding