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Description

Targeting CD38 leads to abrogation of meningeal T H 17 immunity and cortical IL-1, breaking the negative feedback loop between these two compartments

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Glutathione is a tightly regulated intracellular constituent, and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage

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