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The origins of these symptoms are unclear, but they may be related to the stomach inflammation underlying some cases of vitamin B 12 deficiency and to the progressive destruction of the lining of the stomach (21)

POR is widely expressed in the endoplasmic reticulum and donates electrons from nicotinamide adenine dinucleotide phosphate (NADPH) to cytochrome P450 (CYPs) and other proteins[30]