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The GLP-1-activated neurons in the brain also limit appetite for a while after a large meal (e.g., the thought of eating is unappealing for many hours after pigging out on pizza).[ref] Stress-related appetite suppression: Additionally, the GLP-1 neurons activate during times of acute stress to suppress appetite

WT:Gnas fl/fl [saline] p = 0.0163

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Some researchers also investigate combination approaches, pairing GLP-1 agonists with other peptides that target complementary pathways