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Mechanistically, accumulated phosphate activates p38 MAPKa downstream effector of phospholipase A2 signalingwhich in turn promotes eryptosis ( 3.1.4 Vanadate Vanadate, an inorganic uremic toxin, is acquired through environmental exposure and dietary sources

The enzyme is activated allosterically by Sadenosylmethionine (SAM) and also by a cleavage at its carboxyl terminal at R413 to generate a 45 kDa monomer, which is not only twice as active as the full length form but also refractory to SAMmediated activation (Kery et al ., 1998

Journal of Biological Chemistry , 288 (12), 86108618