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Ponirakis G, et al

Severe multisystem symptoms require specialist evaluation Seizures, metabolic strokes, severe weakness, cardiomyopathy, developmental regression, exercise-induced rhabdomyolysis, lactic acidosis, major hearing or vision loss and strong maternal inheritance patterns may require neurological, metabolic or genetic evaluation

In eukaryotic cells, when there is a deficiency of functional mitochondria, the AMP/ATP ratio increases to activate AMPK to induce the expression and phosphorylated activation of PGC-1

This article provides a brief summary of all the indications plus you can refer to our newly published GLP-GIP RA Indication Cheat Sheet here