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53 showed that GSH supplementation had beneficial effects on acute clinical signs of inflammatory bowel disease (IBD), whereas some adverse effects were observed in the chronic stages of IBD in this particular disease model

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Other investigations relate bacterial LPS, altered bile acids, and tryptophan-derived metabolites to microglial priming, BBB malfunction, and worsening of -synuclein aggregation, giving multi-modal evidence of microbiota-driven neurotoxicity [55]

Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging