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The 52-week trial enrolled 1,698 participants across four treatment arms: orforglipron 12mg and 36mg, and oral semaglutide 7mg and 12mg

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doi: 10.3389/fneur.2025.1561000 Received 15 January 2025 Accepted 17 March 2025 Published 02 April 2025 Volume 16 - 2025 Edited by Claudia Altamura, Fondazione Policlinico Campus Bio-Medico, Italy Reviewed by Emel Ur Ozcelik, Istanbul University, Trkiye Adina Maria Roceanu, Bucharest University Emergency Hospital, Romania Updates Copyright 2025 Sun, Chen, Song, Gao and Xu