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Taken together, these functional modules collectively support the core mechanism that a healthy intestinal microbiota maintains immune and joint homeostasis, whereas dysbiosis impairs the intestinal barrier, triggers systemic inflammation, and promotes the progression of rheumatoid arthritis, in which traditional Chinese medicine can exert intervention effects by modulating the microbiota and intestinal barrier

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On the other hand, surprisingly similarly to humans' colonic and fecal values, rumens of herbivores, such as sheep or cows, also contain high levels of acetate, propionate and butyrate, with reported concentrations of 65, 21, and 18 mM, respectively (308)