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The basic threshold: BMI 30 or BMI 27 with comorbidity In obesity treatment, GLP-1 is usually considered at BMI 30 or above, or at BMI 27 to 29.9 together with at least one weight-related comorbidity

Warning signs include: very low urine output dark urine swelling in the legs or ankles extreme tiredness confusion People with existing kidney disease, older adults, or those taking medicines that affect kidney function are at higher risk

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Sensory phenotype and risk factors for painful diabetic neuropathy: a cross-sectional observational study