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And the best part

Research protocols often explore various dosing strategies, with daily administration being common in clinical trials investigating the peptides impact on fat burning and energy metabolism

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again