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Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]
Rapidly proliferating cancer cells have a unique phenotype of iron metabolism, which increases iron supply and decreases iron loss [9]
32 There are low rates of serious and severe infections and of malignancies in those receiving FAE, similar to or lower than with methotrexate, cyclosporine, or biologics
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