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"Your biology is different than mine."

It is essential to recognize that most current evidence comes from preclinical models or small human studies with methodological limitations

In preclinical models, female mice showed greater increases in muscle mass in response to MSTN blockade, whereas male mice demonstrated more prominent reductions in fat mass.[58] However, clinical evidence for sex-based differences in patient outcomes remains limited, partly because most clinical studies have focused on assessing the safety of the drug in postmenopausal women or have primarily targeted elderly individuals with sarcopenia

Extended titration periods, where you spend 6 to 8 weeks at each dose rather than the standard 4 weeks, are supported by the clinical literature and can dramatically improve tolerability