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Jendle J, Nauck MA, Matthews DR, et al

Potential Interference with Oral Contraceptives The second mechanism involves how GLP-1 medications might affect the efficacy of hormonal birth control, particularly oral contraceptives: The slowing down of gastrointestinal transit time, could affect the absorption of oral medications, including birth control pills Side effects like vomiting and diarrhea, could further reduce the effectiveness of oral contraceptives if pills are not properly absorbed Anecdotally, the risk appears to be highest during titration weeks when patients increase their dosage

Gia Balius, Kiana Imani, et al

Efficacy and tolerability of exenatide twice daily and exenatide once weekly in Asian versus White patients with type 2 diabetes mellitus: a pooled analysis