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It was shown that long-term treatment (72 h) of hippocampal slices with BDNF (250 ng/mL) increases synapse number and spine density at the level of apical dendrites of pyramidal neurons in the hippocampus [35], suggesting that BDNF acts selectively on different types of spines, depending on the level of basal, spontaneous synaptic transmission

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The studys lead author told Medical News Today that this data should help doctors and patients alike to make informed choices when treating type 2 diabetes and the implications for people with obesity are significant as well