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SRS is characterized by proportional IUGR with severe SGA at birth, relative sparing of the brain with close to normal head circumference at birth, severe feeding difficulties in infancy and childhood (which in contrast to Prader-Willi syndrome does not rebound into feeding obsession later in life), postnatal growth retardation and body asymmetry

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The DNA methylation is an epigenetic mechanism, able to modify the expression of specific genes without changing the DNA sequence

This is a different approach entirely, combining a GLP-1 agonist with an amylin receptor agonist rather than adding GIP or glucagon