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Compounding, the practice of preparing customized medications tailored to an individual patients needs, serves a legitimate role in the pharmaceutical ecosystem

Some commonly used supplements, like ginkgo, act as anti-coagulants and may increase the risk of bleeding when taken with aspirin, warfarin or another anti-coagulant

The STEP program (including STEP 1 and related trials) demonstrated clinically meaningful weight loss across populations and established semaglutide as a new standard for many patients with obesity

Result tables are provided so the reader may replicate conclusions using a more stringent threshold if needed (Supplementary Table 2)