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Calcium oxalate crystals are recognized by macrophages as foreign particles, triggering the proinflammatory state and macrophage response.[ref][ref] A 2021 study looked at the inflammatory response to dietary oxalates

It reverses damage from free radicals, recharges other depleted antioxidants, supports and maintains the immune system, supports protein structures, and removes heavy metals like mercury circulating through the liver

Add to that an environment filled with ultraprocessed foods, oversized portions, high stress, and limited time for movement, and its no surprise that so many peoples weight ends up yo-yoing despite their best efforts

[DOI] [PMC free article] [PubMed] [Google Scholar] Jones S