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PMID: 40005999)

Specifically, the FDA moved away from aggressive enforcement postures on several key peptides that had been in regulatory limbo: BPC-157 (Body Protection Compound): Removed from the "Category 2" substances list that had restricted its use in compounded medications TB-500 (Thymosin Beta-4 fragment): Similar de-prioritization of enforcement actions against compounding pharmacies MOTS-C : Continued research status maintained without new restrictions This doesn't mean these peptides are FDA-approved drugs

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Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes