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Korpela et al., 2021)

The one piece of cleaner support is Sun 2021 (PMID 34827486), an independent group's APP/PS1 mouse study reporting improved Morris water maze performance, increased synaptophysin, and reduced IL-1/TNF- via PI3K/AKT

Glucagon-like peptide 1 protects pancreatic -cells from death by increasing autophagic flux and restoring lysosomal function

On the other hand, the mitochondrial dynamin-like GTPase (Opa-1) and mitofusin 1 and 2 (Mfn-1/2) are the pro-fusion proteins responsible for maintaining mitochondrial circuitry functions