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Patients should inform their provider about all medications, supplements, and peptides they are taking

Statistical analysis Data were analyzed using one-way analysis of variance (ANOVA) followed by Tukeys post hoc test, performed with GraphPad Prism 9 software (9.5.1, Boston, USA)

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At the 12-month follow-up : 87.5% of patients reported significant relief defined as 50% reduction in baseline pain scores Mean VAS pain score dropped from 7.2 at baseline to 2.8 at 12 months KOOS (Knee Injury and Osteoarthritis Outcome Score) improved across all subscales: pain, symptoms, activities of daily living, sport/recreation, and quality of life No serious adverse events were reported across the treatment period The durability of the response at 12 months is particularly notable