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[11] [12] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and decreased appetite, which are generally mild to moderate in severity and tend to diminish over time

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4.2 GSH/GSSG Imbalance in Aging and Neurodegenerative Disease Because the brain has high energy demand, abundant oxidizable lipids, and strong dependence on mitochondrial function, glutathione metabolism is frequently studied in aging and neurodegeneration

Since the body does not manufacture it, the only way to get it is through diet and/or supplementation