Rapid Risk Reduction Seen in First Months The study found that semaglutide was associated with a 38% reduced risk of major adverse cardiovascular events (MACE) within the first 3 months compared to placebo (36 vs 58, respectively) Within the first 6 months, semaglutide was associated with a 41% reduced risk of MACE compared to placebo (67 vs 113, respectively) Notably, at 3 and 6 months, most patients had not yet lost much weight and many were not yet on the full target dose of semaglutide 2.4 mg weekly
If we then skip meals and fast while eating smaller portions, well likely not get enough protein, energy, and nutrients in our meals to support healthy, sustainable weight loss
Since the combination therapy resulted in the most remarkable improvements in both metrics and corresponding KDIGO risk classification, the combination of dapagliflozin and oral semaglutide shows promise as a future clinical intervention in T2D pharmacological remission
Some individuals experience meaningful blood sugar improvement at this level and remain on 0.5 mg indefinitely