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At the 24-week mark in clinical trials, mean body weight reduction ranged from 7.2% at 1mg to 17.5% at 12mg, compared to 1.6% with placebo

From what I can tell from other comments around the web, its possibly an allergic reaction allergic conjunctivitis and some people have experienced relief with Benadryl and/or steroids, but havent tried either

The scientific validation for liposomal delivery systems has advanced significantly in recent years, moving from theoretical biochemistry to robust human clinical trials

In the latter study, the researchers hypothesized that vitamin B12 may activate an inflammatory process in bacteria that normally lives on the skin, but which can promote acne when inflamed, according to Live Science