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Its biochemical relevance stems from its design as an analog of angiotensin IV, enabling it to interact with specific enzymatic and receptor targets involved in memory formation and neural signaling

Some important risk factors include 5,6 : Older age Family history Unhealthy diet and sedentary lifestyle Smoking Dyslipidemia (imbalanced levels of cholesterol and triglycerides) Hypertension Elevated glucose and insulin levels Chronic kidney disease Obesity High homocysteine levels A range of chronic inflammatory conditions Chronic infections such as human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) It is important to note that a growing proportion of cardiovascular events, including heart attacks, are now occurring in people without well-established risk factors

Journal of Clinical Endocrinology & Metabolism , 107(2), pp.394403

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