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Furthermore, ROS overproduction in myoblasts causes accumulation of S100B, which stimulates NF-B activity, resulting in upregulation of the Ying Yang 1 (YY1) axis and YY1-dependent inhibition of microRNA-133, a promyogenic and anti-adipogenic microRNA, ultimately leading to the transition of myoblasts into adipocytes [110,173,174]

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Beginning with the CY 2023 performance period/2025 MIPS payment year, the additional MIPS payment adjustment for exceptional performance described in section 1848(q)(6)(C) of the Act is no longer available