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This combined approach is particularly prudent for Europa, as locations proposed as natural analogues for the chemistry of Europas ocean are predominantly located at ambient pressure (~0.1 MPa), which differs even from the shallowest depths of Europas ocean (e.g., 20 to 30 MPa)

Why mechanism alone keeps failing this test The history of dermatology and pharmacology is full of compounds with impeccable mechanistic rationales that did not translate into clinical benefit, or that worked by one route and not another

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