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Applied Clinical Genetics, 16 , 3139

These findings provide compelling in vivo evidence for a functional link between lactate reabsorption and uric acid reabsorption in the kidneys

The structure-activity relationship (SAR) studies conducted by Chugai and subsequently by Eli Lilly explored modifications across the molecule's three principal domains: the tetrahydropyran ring system, the indazole heterocycle, and the substituted phenyl ring