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There are tons of chemicals in a single tobacco cigarette, from the chemicals added to the tobacco itself to the chemicals that make up the paper surrounding the tobacco

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While a study found that IQOS was less cytotoxic than CS to human lung epithelial cell line (A549) (9095% estimated reduction in cytotoxicity), both products yielded reduced levels of glutathione (antioxidant) and increased carbonylation of proteins (markers of chronic lung diseases) 23