tirzepatide coming off shortage list FDA Allows Compounded During Review Wegovy off shortage list :

Mild acute pancreatitis was rare and self-limiting [14]

It should be noted that, at steady state, single deviations in oral semaglutide dosing (such as a missed or double dose, a shorter or longer post-dose fasting time, or a dose taken with a larger volume of water) are likely to result in only minor and transient changes in exposure (42)

So while it represents the best oral alternative to injectable tirzepatide, it does not replicate the dual-receptor mechanism that makes tirzepatide uniquely effective

Mounting Evidence Links GLP-1 Drugs to Serious Health Issues For years, scientific studies have showed a link between the GLP-1 drugs and increased risks of serious gallbladder-related diseases and gastrointestinal issues, including: A 2016 study of over 70,000 patients found GLP-1 drugs associated with a significantly increased risk of bile duct and gallbladder disease compared to other oral antidiabetic drugs