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*Correspondence: Zhigang Ren [email protected] Yu [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The initiator of the pathophysiological process has not been elucidated yet, although acute gastrointestinal infections have been found to initiate the symptoms in a certain group of patients with IBS (post-infectious IBS) (81)