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Statistical analysis A sample size of 300 participants provided an effective power of at least 96% for the two co-primary endpoints, and at least 43% for all confirmatory secondary endpoints, which were tested in a predefined hierarchical order (Supplementary Table 4)

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This combinatorial coding capacity underscores the adaptability of the UPS and its capacity to orchestrate diverse cellular outcomes beyond protein destruction

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Rapid improvements in blood glucose levels can temporarily worsen diabetic retinopathy in some individuals

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Docking was performed on a defined receptor grid using the extra precision mode (XP) in the Glide application as described in the Methods section

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