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In a clinical trial of more than 3,000 adults with obesity, participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight -- about 25 pounds on average -- over more than 16 months

Warning signs that should prompt immediate medical evaluation include: Sudden, severe pain in the right upper abdomen or epigastrium Pain radiating to the right shoulder blade or between shoulder blades Nausea and vomiting, especially with abdominal pain Fever or chills accompanying abdominal discomfort Jaundice (yellowing of skin or eyes) Clay-colored stools or dark urine Persistent indigestion or bloating after fatty meals Biliary colicthe classic gallstone symptomtypically presents as episodic right upper quadrant pain lasting 30 minutes to several hours, often triggered by fatty food consumption

Low levels can contribute to fatigue, weakness, low mood, brain fog, or pins and needles

2 Other Medications: Ensure the provider is aware of all medications