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In addition, in the EMPEROR-reduced trial, enrolling about 3700 patients affected by heart failure with reduced ejection fraction (HFrEF), empagliflozin significantly reduced the risk of heart failure hospitalization and decreased total hospitalization for HF regardless of the presence of diabetes or baseline levels of glycohemoglobin (HbA1c) (49, 50)

Sun et al., 2005), and in some lower metazoans such as , a single gene, within the metazoan TrxR family and containing Sec in its C-terminal active site, encodes all known Trx- and GSSG-reductase activities (Bonilla et al., 2008)