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"By shifting GLP-1 exposure toward the brain and away from the periphery, our technology directly addresses key limitations of current injectable and oral GLP-1 therapies." A next-generation GLP-1 strategy Current subcutaneous and oral GLP-1 receptor agonists generate high plasma levels but achieve only limited direct brain exposure, contributing to dose-limiting gastrointestinal side effects and restricting their broader use in CNS-driven indications

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Ces tableaux dmontrent par consquent le caractre imprvisible et inattendu de l'effet de synergie observ, qui est la base de la prsente invention.These tables therefore demonstrate the unpredictable and unexpected nature of the observed synergistic effect, which is the basis of the present invention