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Third, whereas smoking-attributable mortality is still increasing for many older female cohorts, it is declining for females in the more recent cohorts in the US and Europe, as well as for males in all three regions
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Nicotine, the principal component of TS and e-cig, can negatively affect tight junctional protein expression, compromising BBB integrity ( Moreover, the comparative effect of TS and e-cig extract showed that downregulation of ZO-1 protein from e-cig was not dissimilar to that from TS extract treatment (Kaisar et al., 2017)
Thus, age and nicotine exposure may influence executive brain function 35
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