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These data demonstrate that metformin alters metabolism, specifically inhibiting oxidative phosphorylation, and induces significant mitochondrial dysfunction in both HCT116 and SW837 cells, supporting its metabolic modulatory effects in CRC in vitro

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117,118 Promoting M1 macrophage polarization and inhibiting M2 polarization promotes the intestinal inflammatory response, as it significantly increases the expression of CD73 in the colonic mucosal tissues of UC patients