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An interesting preclinical study explored the activity of PIO, metformin (MET) and dapagliflozin (DAPA) individually and in combinations vs

According to current guidelines, they should be avoided if you are pregnant, hypersensitive to GLP-1, or living with severe gastrointestinal conditions such as inflammatory bowel disease (IBD)

Meals become smaller, snacking decreases, and the constant preoccupation with food that many people with obesity experience begins to fade

This offered a breakthrough for the pharmaceutical industry as the medication demonstrated proven weight loss as an advantage over other type 2 diabetes agents available at the time