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There are a number of possible mechanisms [390], but one perspective is that the pulses produce inhibitory neuronal effects on somata that are proximal to the location of the electrode

Ultimately, this cycle impairs antioxidant defenses and drives a self-reinforcing process that hastens AD progression

Glutathione and insulin are just two of the many intranasal compounds Parkinsons and Alzheimers researchers are checking out

Djavaheri-Mergny M, Javelaud D, Wietzerbin J, Besanon F (2004) NF-kappaB activation prevents apoptotic oxidative stress via an increase of both thioredoxin and MnSOD levels in TNFalpha-treated Ewing sarcoma cells