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An early study by Jackson and Halestrap (130) documented lactate-induced intracellular acidification in rat hepatocytes, whereas Bozzo et al (131) observed only modest pH reductions following 5 mM lactate treatment in mouse neurons

In contrast to GLP-1 mono-therapy, GLP-1/estrogen co-agonism prevented hyperphagia and beta-cell failure in NZO mice (Schwenk et al., 2014)

These benefits held whether patients had type 2 diabetes or not

For example, incidence of biliary disease (per 1000 person-years) was 11.7 for semaglutide, 18.6 for liraglutide, and 12.6 for bupropion-naltrexone and 4.6, 7.9, and 1.0, respectively, for pancreatitis