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These cells exhibited high Wnt signaling, expressed self-renewal genes, and were capable of differentiation into effector TCF1 low CD8+ T cells that relocated into the pancreas ( high stem-like T cells could induce T1D while as many as 100,000 TCF1 low cells did not ( high cells, and determine whether these autoreactive T cells can lead to the destruction of cells using human in vitro models

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