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(2007) examined the generation and distribution of protein oxidation adducts with acetaldehyde and lipid peroxidation products: MDA and hydroxynonenal (HNE), as well as ethanol-stimulated expression of CYP2E1 in the oral mucosa of the alcohol-dependent patients diagnosed with leukoplakia (pre-cancerous condition) and squamous cell carcinoma (SCC)

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In contrast, DFP treatment significantly decreased Fe 2+ levels in optic nerve tissue, downregulated TFR1 and Iba-1 expression, and inhibited iron deposition, ferroptosis, microglial activation, and astrocyte proliferation, thereby reducing myelin loss and optic nerve damage in MS mice (Rayatpour et al., 2022)