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It is normally secreted from the intestine upon ingestion of glucose, fatty foods or nutrients to stimulate insulin secretion by pancreas

Approximately 1213% of acute overdoses result in hepatotoxicity even with treatment [Citation29], with 25% progressing to liver failure [Citation30] and 0.20.5% resulting in death [Citation30]

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10.1186/s13287-017-0694-z Summary Keywords GLP-1, GLP-1RAs, T2DM, glucose, mechanism Citation He X, Zhao W, Li P, Zhang Y, Li G, Su H, Lu B and Pang Z (2025) Research progress of GLP-1RAs in the treatment of type 2 diabetes mellitus