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This patient demonstrated improvement in psychiatric symptoms with start and titration of tirzepatide and worsening in psychiatric symptoms with taper and discontinuation of tirzepatide (see Figure 1)

However, as with any comprehensive supplement protocol for complex chronic illness, it is imperative to work closely with a knowledgeable healthcare provider who can tailor the approach to your specific biochemical needs and monitor for any unexpected reactions

The retrospective design and small sample size limit generalizability and precluded formal power calculation or multivariate analysis

doi: 10.1038/s41401-018-0196-2 146 HanCLiYZhangYWangYCuiDLuoTet al