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As an insulinotropic hormone, GLP-1 plays a substantial role in the regulation of glucose homeostasis, not only in the periphery but also in the central nervous system [90]

Current management strategies mainly involve the use of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), biological DMARDs, and targeted synthetic DMARDs combined with glucocorticoids to alleviate inflammation and pain [3]

This positions it as an appealing option for those who have not met their goals with tirzepatide vs retatrutide or who desire a more assertive approach to managing their condition

It serves as a primary line of defense against cellular wear and tear and supports the natural detoxification pathways in the liver