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120 In humans, higher serum fasting GIP concentrations were associated with an unhealthy body fat distribution independent of plasma insulin concentration, and genome-wide association studies found associations between body mass index, body fat distribution and increased visceral fat accumulation with single nucleotide polymorphisms of the GIPR locus

In osteoarthritis conditions, preclinical models highlight direct anti-catabolic and immunomodulatory actions (e.g., liraglutide reduces IL-6, MMP-3) [45]

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