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The risk of major hemorrhage was 5.3-fold before therapy stabilization, 2.2-fold after therapy stabilization, and 2.4-fold during all periods when anticoagulation was not stable

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While the protection of normal cells against radiation-induced cell death by ebselen has been attributed to its ability to detoxify cellular/mitochondrial ROS through the GPx mechanism, the molecular mechanism contributing to its radio-sensitization effect in cancer cells is still not fully understood

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