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17 Leading from this, assumptions have been made that the gastric motility effects of longer acting GLP-1RAs are reduced with prolonged dosing

Several major observational studies provide strong evidence: A retrospective analysis that tracked 64,000 patients found thyroid cancer risk 65% higher than metformin users [2] Scientists conducting a French case-control study of 2,562 patients and 45,184 controls discovered a 58% increased risk for all thyroid carcinomas[3] The EudraVigilance database showed 236 thyroid cancer cases among GLP-1RA users from a population of 6.6 million people [3] Clinical trial data tells a different story