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The REDEFINE Phase 3 Program (2025) The Phase 3 evidence for the cagrilintide-semaglutide combination was reported under the REDEFINE program in the New England Journal of Medicine in 2025

Uncontrolled external factors like diet, medication (e.g., beta-blockers), and comorbidities introduce confounding variables, while variability in control samples (age, sex differences) undermines biomarker specificity

and 10% in the rest of the world are likely to be treated with GLP-1 therapies by 2035, up from approximately 6% in the U.S

In some regions, 8-20% of people have a more severe form, reducing enzyme activity to just 30%